1-Benzotriazolamine, ABT
1-Aminobenzotriazole
CAS: 1614-12-6
Molecular Formula: C6H6N4
1-Benzotriazolamine, ABT - Names and Identifiers
1-Benzotriazolamine, ABT - Physico-chemical Properties
| Molecular Formula | C6H6N4 |
| Molar Mass | 134.14 |
| Density | 1.2769 (rough estimate) |
| Melting Point | 81-84 °C (lit.) |
| Boling Point | 237.24°C (rough estimate) |
| Flash Point | 146.9°C |
| Water Solubility | slightly soluble |
| Solubility | Soluble in DMSO (up to 30mg/ml) |
| Vapor Presure | 0.000341mmHg at 25°C |
| Appearance | Yellow to beige or light brown crystalline powder |
| Color | Yellow to beige or light brown |
| BRN | 607843 |
| pKa | 2.09±0.30(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Refractive Index | 1.7000 (estimate) |
| MDL | MFCD00132902 |
| Physical and Chemical Properties | WGK Germany:3 |
| In vitro study | 1-Aminobenzotriazole (ABT) alone significantly increases the expression levels of CYP2B6 in two different hepatocytes (7.3- and 10.8-fold, respectively). Upon co-treatment with 1-Aminobenzotriazole, the induction of CYP2B6 expression by CITCO or rifampin is potentiated: 12.6- and 4.0-fold for CITCO as well as 3.9- and 2.5-fold for rifampin. 1-Aminobenzotriazole has a greater potentiation effect on CITCO than on rifampin. 1-Aminobenzotriazole alone increases the expression levels of CYP3A4 in tow different hepatocytes (by 2.0- and 3.8-fold). Upon co-treatment with 1-Aminobenzotriazole, the effects of CITCO on CYP3A4 expression levels are potentiated by 3.8- and 6.0- fold as compare to cells treated with CITCO alone. 1-Aminobenzotriazole (ABT) (1 mM) shows pronounced (~95%) inhibition of the formation of N-acetylprocainamide compare with the control without 1-Aminobenzotriazole. |
| In vivo study | Oral 1-Aminobenzotriazole (ABT) (100 mg/kg, 2 h predose) decreases the clearance of intravenous procainamide (45%) in rats, accompanied by a decreased N-acetylprocainamide-to-procainamide ratio in urine (0.74 versus 0.21) and plasma (area under the curve ratio 0.59 versus 0.11). The urinary recovery of procainamide increases from 18 to 30%, whereas the recovery of N-acetylprocainamide in urine decreases from 13.3 to 6.5% with 1-Aminobenzotriazole. Pretreatment of rats with 100 mg/kg oral 1-Aminobenzotriazole (ABT) administered 2 hours before a semisolid caloric test meal markedly delays gastric emptying. 1-Aminobenzotriazole also increases stomach weights by 2-fold. |
1-Benzotriazolamine, ABT - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| RTECS | DM1235000 |
| HS Code | 29349990 |
| Hazard Note | Irritant |
1-Benzotriazolamine, ABT - Reference
| Reference Show more | 1. Li Yixin Wanqun Xu Wenjun et al. Effects of Metabolic Inhibitors and P450s Inhibitors on Thiamethoxam Absorption by Shanghai Green [J]. Jiangsu Agricultural Sciences 2020 048(004):172-176. |
1-Benzotriazolamine, ABT - Reference Information
| Biological activity | 1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a non-selective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT). |
| Target | Value |
Last Update：2024-04-10 22:29:15
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